The bendesky lab


Zuckerman Mind Brain Behavior Institute, E3B, Columbia University

What we do

The diversity of animal behavior is fascinating, yet we know little about how behavior evolves.
We take genetic, genomic, molecular, and neurobiological approaches to understand the mechanisms underlying the natural variation and evolution of behavior.
Our work focuses mostly on exploratory and social behaviors – like pair bonding and parental care – in Peromyscus mice, and on aggression in Siamese Fighting Fish (Betta splendens).

© drawings of Betta sp. by Jordan Ahava

People

Bendesky Lab and friends, May 2021


Andrés Bendesky

Principal Investigator

Andrés got his MD from UNAM, Mexico, his PhD from Rockefeller University, and was a Helen Hay Whitney Fellow at Harvard. He is interested in how complex behaviors are generated by the brain and how they evolve.

Kerel Francis

Lab Manager and Research Assistant

Kerel received his MSc in Neuroscience from the University of Bremen. Currently he is working in collaboration with the Kӧnig lab at the University of Zurich whose aim is to understand the evolution of social behavior in mice.

Alec Palmiotti

Research Assistant

Alec received his BA from Oberlin College studying Neuroscience and Hispanic Studies. He is currently working on developing genetically modified Betta fish and helps coordinating the fish facility.

Amy Norovich

Postdoc

Amy received her PhD from Columbia University and her BSc from MIT. She is studying the neural basis of sexually dimorphic behaviors in Betta splendens.

Christoph Gebhardt

Postdoc

Chris received his PhD from KIT and was a postdoc in Filippo Del Bene's lab in Paris. He aims to understand the neural basis of differences in parental care behavior in Peromyscus.

Pei-Yin Shih

Postdoc

Pei received her PhD from Caltech working in the lab of Paul Sternberg. She is studying the genetic basis of aggression in Betta splendens.

Jennifer Merritt

Postdoc

Jenny received her PhD from Emory University. She is studying the neural and genetic mechanisms of alternative life histories in closely related species of Peromyscus.

Joshua Greene

Postdoc

Josh received his MD from Cornell and a PhD from Rockefeller University. He is studying CNS regulation of the adrenomedullary system in Peromyscus.

Natalie Niepoth

PhD Student (E3B program)

Natalie got her BSc from Rice University and a masters in evolutionary biology from the University of Amsterdam. She is studying the genetic basis of anxiety and exploration in Peromyscus mice.

Claire Everett

PhD Student (NBB program)

Claire received her BA from Barnard College. She is studying the visual cues critical for evoking aggression in Betta splendens. She is also interested in the neural circuits underlying Betta visual processing of aggression-inducing stimuli.

Kimberly Hernandez

PhD Student (NBB program)

Kim is a PhD student in the lab jointly supervised by Andrés and Steven Siegelbaum.

Wyatt Toure

PhD Student (E3B program)

Wyatt received his B.Sc. from Concordia University and his M.Sc. from McGill University. He is interested in the evolution of molecular mechanisms underlying adaptive phenotypes.

Julio Bendesky

Lab Mascot

Julio is a dachshund and really good at detecting and retrieving food (that belongs to others).


Lab Alumni

Madison Lichak

Undergrad & Research Assistant

Young Mi Kwon

Research Assistant

Jan-Niklas Runge

PhD student & Postdoc

Wenxuan Dan

Master student

Yuqi Miao

Master student

Hiroki Tomida

Master student (E3B program)

Yuyang Zhu

Master student

Debbie Leung

Undergrad

Elaine Lee

Undergrad

Bliss Bagnato-Conlin

Undergrad

Peter Lichtenthal

Undergrad

Joseph Brew

Undergrad

Emily Lei

Undergrad

Christina Lin

Undergrad

Publications

Care and Use of Siamese Fighting Fish (Betta splendens) for Research.
Lichak MR, Barber JR, Kwon YM, Francis KX, Bendesky A
Comp Med. 2022 Jun 14;72(3):169-180

Genomic consequences of domestication of the Siamese fighting fish.
Kwon YM, Vranken N, Hoge C, Lichak MR, Francis KX, Camacho-Garcia J, Bista I, Wood J, McCarthy S, Chow W, Tan HH, Howe K, Bandara S, von Lintig J, Rüber L, Durbin R, Svardal H, Bendesky A
Sci Adv. 2022 Mar 11;8(10):abm4950

Media coverage
Annie Roth. The 1,000-Year Secret That Made Betta Fish Beautiful. New York Times. May 14, 2021.
Sarah Zhang. The Surprise Hiding in the DNA of Pet Fish. The Atlantic. May 14, 2021.
Christie Wilcox. My Daughter’s First Pet—the Next Big Model Organism? The Scientist. Jul 15, 2021.

Parent-offspring inference in inbred populations.
Runge JN, Koenig B, Lindholm AK, Bendesky A
bioRxiv 2021. doi: 10.1101/2021.11.23.469656

How the mind affects the body. Bendesky A
Kandel Quarterly, 8 July 2021. McGraw Hill, 2021. AccessNeurology

The neurobiology and evolution of niche preferences. Bendesky A
Kandel Quarterly, 13 October 2021. McGraw Hill, 2021. AccessNeurology

Loop-Mediated Isothermal Amplification Detection of SARS-CoV-2 and Myriad Other Applications.
Moore KJM, Cahill J, … Bendesky A, … Mason CE, The gLAMP Consortium
J Biomol Tech. 2021 Sep;32(3):228-275

WHotLAMP: A simple, inexpensive, and sensitive molecular test for the detection of SARS-CoV-2 in saliva.
Ng D, Pinharanda A, Vogt MC… Bendesky A
PLoS ONE 2021 Sep 16 16(9):e0257464

How Natural Genetic Variation Shapes Behavior.
Niepoth N, Bendesky A
Annu Rev Genomics Hum Genet. 2020 Apr 13

Generation, Coordination, and Evolution of Neural Circuits for Vocal Communication
Kelley DB, Ballagh IH, Barkan CL, Bendesky A, Elliott TM, Evans BJ, Hall IC, Kwon YM, Kwong-Brown U, Leininger EC, Perez EC, Rhodes HJ, Villain A, Yamaguchi A, Zornik E
J Neurosci. 2020 Jan 2;40 (1) 22-36.

The genetic basis of parental care evolution in monogamous mice
Bendesky A, Kwon YM, Lassance J, Lewarch CL, Yao S, Peterson BK, He MX, Dulac C, Hoekstra HE
Nature. 2017 Apr 27;544(7651):434-9.

Scientific and media coverage
News and Views: Phelps SM. Animal behaviour: How to build a better dad. Nature. 2017;544:418–419.
Snyder-Mackler M, Tung J. Vasopressin and the Neurogenetics of Parental Care. Neuron. 2017;95:9-11
Hager R. The Genes That Make a Good Parent. Trends in Genetics. 2017;33:492-494.
Media Coverage: Carl Zimmer. Why Are Some Mice (and People) Monogamous? A Study Points to Genes. New York Times. April 19, 2017.
Andrea Marks. The Mouse Parent Trap. Scientific American. July 2017.

Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans.
Bendesky A, Pitts J, Rockman MV, Chen WC, Tan MW, Kruglyak L, Bargmann CI
PLoS Genet. 2012;8(12):e1003157.

Genetic contributions to behavioural diversity at the gene-environment interface.
Bendesky A, Bargmann CI
Nat Rev Genet. 2011 Nov 8;12(12):809-20.

Catecholamine receptor polymorphisms affect decision-making in C. elegans.
Bendesky A, Tsunozaki M, Rockman MV, Kruglyak L, Bargmann CI
Nature. 2011 Apr 21;472(7343):313-8.

GFP Reconstitution Across Synaptic Partners (GRASP) defines cell contacts and synapses in living nervous systems.
Feinberg EH, Vanhoven MK, Bendesky A, Wang G, Fetter RD, Shen K, Bargmann CI
Neuron. 2008 Feb 7;57(3):353-63.

2022

March 11: The lab's paper about genomic consequences of Betta fish domestication is finally out in Science Advances. Congratulations, everyone. :-)

February 1: Joseph received a prestigious Kellett Fellowship to pursue a MPhil in Computational Biology at Cambridge University, UK. Congratulations, Joseph. :-)

2021

November 24: We published a new pre-print on biorxiv on how to infer Parent-offspring relationships in inbred populations.

September 1: Wyatt joins the lab as PhD student in the E3B program. Welcome, Wyatt!

June 28: Alec joins the lab as research assistant. Welcome, Alec!

April 30: The lab's first ever pre-print was uploaded on biorxiv. It is about the genomic consequences of Betta fish domestication.

March 15: Josh joins the lab as a postdoc. Welcome, Josh!

February 17: The new TWIN about the connection between the Microbiome and Neurodevelopment is out.

2020

December 3: Jenny is selected as a Junior Fellow of the Simons Society of Fellows. Congratulations, Jenny!

October 1: Jenny joins the lab as postdoc. Welcome, Jenny!

August 1: Jan re-joins the lab as postdoc supported by a Early Postdoc.Mobility Fellowship of the Swiss National Science Foundation. Congratulations and welcome back, Jan!

April 18: The new TWIN Podcast is out, this time talking about Anosmia connected to Covid-19.

April 13: New review article published on how behavior is being shaped by genetic variation

April 1: Elaine was admitted to the Laidlaw Undergraduate Research Program to support her work in the lab during the summer. Congratulations, Elaine!

March 31: Kimberly received an Honorable Mention for the NSF GRFP. Congratulations, Kim!

January 9: Andrés again joins the TWIN Podcast covering ACBARs, virus-like capsids that transfer genetic information between neurons

January 2: Review article with Darcy Kelley on vocal communication in Xenopus frogs published

2019

November 5: Andrés talks about work in the lab and about synaptic transmission and plasticity in the new Podcast "This Week In Neuroscience" (TWIN)

August 29: Magdalen and her work are featured on the Barnard College youtube channel.

August 16: Pei-Yin starts her postdoc in the lab, Hiroki (E3B MA Program) joins the lab

August 1: Kim (NB&B) starts her PhD in the lab

April 1: Christoph starts his postdoc in the lab.

March 31: Claire received an Honorable Mention for the NSF GRFP. Congratulations, Claire!

February 19: Andrés is named a 2019 Sloan Research Fellow in Neuroscience. News here

February 1: Young Mi joins the lab as Research Assistant

January: Amy is selected as a Junior Fellow of the Simons Society of Fellows. Congratulations, Amy!

2018

August 20: Claire (NB&B) joins the lab as PhD student

July 1: Madison re-joins the lab as Research Assistant

May 15: Andrés is awarded a Klingenstein-Simons Fellowship Award in Neuroscience

April 4: Andrés is named a Searle Scholar. News here

March 19: Amy starts her postdoc in the lab

March 1: Emily joins the lab for her undergraduate thesis

January 15: Magdalen joins the lab as part of her senior neuroscience thesis project

2017

September 1: Natalie (E3B) starts her PhD in the lab, Madison joins the lab for her undergraduate thesis

August 1: Lab opens

Contact

Andrés Bendesky
Jerome L. Greene Science Center
Columbia University
3227 Broadway, Room L3.051
New York, NY 10027
1-212-853-1174
andres@bendeskylab.com